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Experience is limited in patients with severe and moderate renal impairmentsee CLINICAL PHARMACOLOGY

CommentsAdminister this drug in combination with aspirin 75 mg to 325 mg orally once a dayThe benefit of this drug for patients who undergo primary percutaneous coronary intervention is unknown.

A randomizedplacebo-controlled trialCLARINETdid not demonstrate a clinical benefit of clopidogrel in neonates and infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary arterial shuntPossible factors contributing to this outcome were the dose of clopidogrelthe concomitant administration of aspirin and the late initiation of therapy following shunt palliationIt cannot be ruled out that a trial with a different design would demonstrate a clinical benefit in this patient population.

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